Western Blot (WB)
(ZNRF1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ZNRF1 antibody detected the ZNRF1 protein (arrow).)
Rabbit ZNRF1 Polyclonal Antibody | anti-ZNRF1 antibody
ZNRF1 Antibody (Center)
Western Blot (WB)
(ZNRF1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ZNRF1 antibody detected the ZNRF1 protein (arrow).)
Western Blot (WB)
(ZNRF1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ZNRF1 antibody detected the ZNRF1 protein (arrow).)
in response to nerve damage, a gene which is highly expressed in
ganglia and in the central nervous system was found. The protein
encoded by the rat gene contains both a zinc finger and a RING
finger motif and is localized in the endosome/lysosome compartment,
indicating that it may be involved in ubiquitin-mediated protein
modification. The protein encoded by this human gene is highly
similar in sequence to that encoded by the rat gene. [provided by
RefSeq].
Yoshida, K., et al. Biochem. Biophys. Res. Commun. 389(3):506-511(2009)
Markson, G., et al. Genome Res. 19(10):1905-1911(2009)
van Wijk, S.J., et al. Mol. Syst. Biol. 5, 295 (2009) :
Araki, T., et al. J. Neurosci. 23(28):9385-9394(2003)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]
Uniprot Description
ZNRF1: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; EC 6.3.2.-; Ligase; EC 6.3.2.19; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 16q23.1
Cellular Component: membrane; synaptic vesicle membrane; lysosome; cytosol; cell junction; endosome
Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process
Research Articles on ZNRF1
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Product Notes
The ZNRF1 znrf1 (Catalog #AAA9214618) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 59-86. The ZNRF1 Antibody (Center) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's ZNRF1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ZNRF1 znrf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZNRF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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