ZFYVE16 blocking peptide

ZFYVE16 Antibody (N-term) Blocking Peptide

• Gene Names: ZFYVE16; PPP1R69
• Synonyms: ZFYVE16; ZFYVE16 Antibody (N-term) Blocking Peptide; Zinc finger FYVE domain-containing protein 16; Endofin; Endosome-associated FYVE domain protein; KIAA0305; ZFYVE16 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1539

• Cellular Location: Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note: Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P)
• Tissue Location: Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ZFYVE16 blocking peptide

May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.

NCBI and Uniprot Product Information

• NCBI GI #: 296453075
• NCBI GeneID: 9765
• UniProt Accession #: Q7Z3T8; O15023; Q5H9U2; Q7LAU7; Q86T69; Q8N5L3; Q8NEK3
• Molecular Weight: 88,377 Da
• NCBI Official Full Name: Zinc finger FYVE domain-containing protein 16
• NCBI Official Synonym Full Names: zinc finger FYVE-type containing 16
• NCBI Official Symbol: ZFYVE16
• NCBI Official Synonym Symbols: PPP1R69
• NCBI Protein Information: zinc finger FYVE domain-containing protein 16
• UniProt Protein Name: Zinc finger FYVE domain-containing protein 16
• Protein Family: Zinc finger FYVE domain-containing protein
• UniProt Gene Name: ZFYVE16
• UniProt Synonym Gene Names: KIAA0305
• UniProt Entry Name: ZFY16_HUMAN

NCBI Description

This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

endofin: May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 5q14

Cellular Component: cytoplasm; early endosome; early endosome membrane; intracellular membrane-bound organelle

Molecular Function: phosphatidylinositol binding; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein transporter activity

Biological Process: BMP signaling pathway; endosome transport; protein targeting to lysosome; regulation of endocytosis