YBX2 blocking peptide

YBX2 Antibody (C-term) Blocking Peptide

• Gene Names: YBX2; DBPC; MSY2; CSDA3; CONTRIN
• Synonyms: YBX2; YBX2 Antibody (C-term) Blocking Peptide; Y-box-binding protein 2; Contrin; DNA-binding protein C; Dbpc; Germ cell-specific Y-box-binding protein; MSY2 homolog; CSDA3; MSY2; YBX2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human YBX2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 364

• Cellular Location: Cytoplasm. Nucleus
• Tissue Location: Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for YBX2 blocking peptide

Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 116242847
• NCBI GeneID: 51087
• UniProt Accession #: Q9Y2T7; Q8N4P0; D3DTP1
• Molecular Weight: 38,518 Da
• NCBI Official Full Name: Y-box-binding protein 2
• NCBI Official Synonym Full Names: Y-box binding protein 2
• NCBI Official Symbol: YBX2
• NCBI Official Synonym Symbols: DBPC; MSY2; CSDA3; CONTRIN
• NCBI Protein Information: Y-box-binding protein 2
• UniProt Protein Name: Y-box-binding protein 2
• Protein Family: Y-box-binding protein
• UniProt Gene Name: YBX2
• UniProt Synonym Gene Names: CSDA3; MSY2; Dbpc
• UniProt Entry Name: YBOX2_HUMAN

NCBI Description

This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012]

Uniprot Description

YBX2: Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay.

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: nucleolus; nucleus

Biological Process: spermatogenesis; transcription from RNA polymerase II promoter; translational attenuation