XPC blocking peptide

XPC Blocking Peptide(N-term)

• Gene Names: XPC; XP3; RAD4; XPCC; p125
• Synonyms: XPC; XPC Blocking Peptide(N-term); DNA repair protein complementing XP-C cells; Xeroderma pigmentosum group C-complementing protein; p125; XPCC; XPC blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 169-183 of HUMAN XPC
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 140

• Cellular Location: Nucleus. Cytoplasm. Note: Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for XPC blocking peptide

Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA- binding activity.

NCBI and Uniprot Product Information

• NCBI GI #: 224809302
• NCBI GeneID: 7508
• NCBI Accession #: NP_001139241.1
• NCBI GenBank Nucleotide #: NM_001145769.1
• UniProt Accession #: Q01831; Q53GT7; Q96AX0; B4DIP3; E9PB96; E9PH69
• Molecular Weight: 15,712 Da
• NCBI Official Synonym Full Names: XPC complex subunit, DNA damage recognition and repair factor
• NCBI Official Symbol: XPC
• NCBI Official Synonym Symbols: XP3; RAD4; XPCC; p125
• NCBI Protein Information: DNA repair protein complementing XP-C cells
• UniProt Protein Name: DNA repair protein complementing XP-C cells
• Protein Family: DNA repair protein
• UniProt Gene Name: XPC
• UniProt Synonym Gene Names: XPCC
• UniProt Entry Name: XPC_HUMAN

NCBI Description

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

XPC: a probable nuclear protein involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane

Molecular Function: bubble DNA binding; damaged DNA binding; loop DNA binding; protein binding; single-stranded DNA binding

Biological Process: DNA repair; mismatch repair; nucleotide-excision repair; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, preincision complex assembly; protein sumoylation

Disease: Xeroderma Pigmentosum, Complementation Group C