WDR5 blocking peptide

WDR5 Peptide

Cat. Num. AAA152365

• Gene Names: WDR5; SWD3; BIG-3; CFAP89
• Applications: Blocking (BL)
• Synonyms: WDR5; WDR5 Peptide; SWD3; BIG-3; BIG3; WD repeat-containing protein 5; BMP2-induced 3-kb gene protein; WD repeat domain 5; WDR5 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 334

• Applicable Applications for WDR5 blocking peptide: Blocking (BL)
• Application Notes: WDR5 peptide is used for blocking the activity of WDR5 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 19 amino acid peptide near the amino terminus of human WDR5.
• Preparation and Storage: Store WDR5 peptide at -20 degree C, stable for one year.

Western Blot (WB)

(Western blot analysis of WDR5 in 293 cell lysate with WDR5 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 16554627
• NCBI GeneID: 11091
• NCBI Accession #: NP_060058
• NCBI GenBank Nucleotide #: NM_017588.2
• UniProt Accession #: P61964; Q91VA5; Q9NWX7; Q9UGP9
• Molecular Weight: 36,588 Da
• NCBI Official Full Name: WD repeat-containing protein 5
• NCBI Official Synonym Full Names: WD repeat domain 5
• NCBI Official Symbol: WDR5
• NCBI Official Synonym Symbols: SWD3; BIG-3; CFAP89
• NCBI Protein Information: WD repeat-containing protein 5; WD-repeat protein 5; BMP2-induced 3-kb gene protein; SWD3, Set1c WD40 repeat protein, homolog; cilia and flagella associated protein 89
• UniProt Protein Name: WD repeat-containing protein 5
• Protein Family: WD repeat-containing protein
• UniProt Gene Name: WDR5
• UniProt Synonym Gene Names: BIG3
• UniProt Entry Name: WDR5_HUMAN

NCBI Description

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

WDR5: a WD40 repeat protein. May accelerate osteoblast differentiation. Interacts with HCFC1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: nucleoplasm; histone methyltransferase complex; nucleus; histone acetyltransferase complex

Molecular Function: protein binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone acetyltransferase activity (H4-K16 specific)

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; histone H3-K4 methylation; skeletal development