VPS45 blocking peptide

VPS45 Antibody (C-term) Blocking Peptide

• Gene Names: VPS45; H1; SCN5; VSP45; VPS45A; VPS45B; VPS54A; VSP45A; H1VPS45
• Synonyms: VPS45; VPS45 Antibody (C-term) Blocking Peptide; Vacuolar protein sorting-associated protein 45; h-VPS45; hlVps45; VPS45A; VPS45B; VPS45 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 570

• Cellular Location: Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein Note: Associated with Golgi/endosomal vesicles and the trans-Golgi network.
• Tissue Location: Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for VPS45 blocking peptide

May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.

NCBI and Uniprot Product Information

• NCBI GI #: 23396937
• NCBI GeneID: 11311
• UniProt Accession #: Q9NRW7; Q15715; Q53FR8; Q5T4P6; Q9Y4Z6; D3DUZ9; F5H8K1
• Molecular Weight: 61,983 Da
• NCBI Official Full Name: Vacuolar protein sorting-associated protein 45
• NCBI Official Synonym Full Names: vacuolar protein sorting 45 homolog
• NCBI Official Symbol: VPS45
• NCBI Official Synonym Symbols: H1; SCN5; VSP45; VPS45A; VPS45B; VPS54A; VSP45A; H1VPS45
• NCBI Protein Information: vacuolar protein sorting-associated protein 45
• UniProt Protein Name: Vacuolar protein sorting-associated protein 45
• Protein Family: Vacuolar protein sorting-associated protein
• UniProt Gene Name: VPS45
• UniProt Synonym Gene Names: VPS45A; VPS45B; h-VPS45; hlVps45
• UniProt Entry Name: VPS45_HUMAN

NCBI Description

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

Uniprot Description

VPS45A: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. Belongs to the STXBP/unc-18/SEC1 family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: endosome membrane; Golgi apparatus; Golgi membrane; integral to membrane

Molecular Function: protein binding

Biological Process: blood coagulation

Disease: Neutropenia, Severe Congenital, 5, Autosomal Recessive