TRPM6 (CHAK2) Blocking Peptide | TRPM6 blocking peptide
TRPM6 (CHAK2) Antibody (Center) Blocking peptide
NCBI and Uniprot Product Information
NCBI Description
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]
Uniprot Description
ChaK2: is an unusual bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. ChaK2 mutations cause hereditary hypomagnesemia and secondary hypocalcemia (HSH). The TRP voltage-independent calcium-permeable cation channels are divided into six subfa milies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Related to ChaK1, another Atypical alpha kinase fused to a TRP ion channel protein. Forms homodimers or heterodimers with ChaK1. Six alternatively spliced isoforms have been described, three of which lack the ion channel region.
Protein type: Kinase, protein; EC 2.7.11.1; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation; Protein kinase, atypical; ATYPICAL group; Alpha family; ChaK subfamily
Chromosomal Location of Human Ortholog: 9q21.13
Cellular Component: plasma membrane
Molecular Function: calcium channel activity; protein binding
Biological Process: response to toxin
Disease: Hypomagnesemia 1, Intestinal
Research Articles on TRPM6
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Product Notes
The TRPM6 trpm6 (Catalog #AAA9227495) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TRPM6 (CHAK2), Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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