Western Blot (WB)
(Western Blot analysis of Human jejunoileum and ileum tissue using TRPM6 Polyclonal Antibody at dilution of 1:200)
Rabbit anti-Human TRPM6 Polyclonal Antibody | anti-TRPM6 antibody
TRPM6 Polyclonal Antibody
Western Blot (WB)
(Western Blot analysis of Human jejunoileum and ileum tissue using TRPM6 Polyclonal Antibody at dilution of 1:200)
Western Blot (WB)
(Western Blot analysis of Human jejunoileum and ileum tissue using TRPM6 Polyclonal Antibody at dilution of 1:200)
NCBI and Uniprot Product Information
NCBI Description
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]
Uniprot Description
ChaK2: is an unusual bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. ChaK2 mutations cause hereditary hypomagnesemia and secondary hypocalcemia (HSH). The TRP voltage-independent calcium-permeable cation channels are divided into six subfa milies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Related to ChaK1, another Atypical alpha kinase fused to a TRP ion channel protein. Forms homodimers or heterodimers with ChaK1. Six alternatively spliced isoforms have been described, three of which lack the ion channel region.
Protein type: Protein kinase, atypical; Membrane protein, integral; Membrane protein, multi-pass; EC 2.7.11.1; Channel, cation; Kinase, protein; ATYPICAL group; Alpha family; ChaK subfamily
Chromosomal Location of Human Ortholog: 9q21.13
Cellular Component: brush border membrane; apical plasma membrane; plasma membrane; integral to membrane
Molecular Function: protein serine/threonine kinase activity; protein binding; calcium channel activity; metal ion binding; ATP binding
Biological Process: response to toxin; transmembrane transport; protein amino acid phosphorylation
Disease: Hypomagnesemia 1, Intestinal
Research Articles on TRPM6
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Product Notes
The TRPM6 trpm6 (Catalog #AAA2529183) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TRPM6 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TRPM6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). WB: 1:200-1:1000. Researchers should empirically determine the suitability of the TRPM6 trpm6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRPM6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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