TRPM4 blocking peptide

TRPM4 Antibody (C-term) Blocking Peptide

• Gene Names: TRPM4; LTrpC4; PFHB1B; TRPM4B; hTRPM4
• Synonyms: TRPM4; TRPM4 Antibody (C-term) Blocking Peptide; Transient receptor potential cation channel subfamily M member 4; hTRPM4; Calcium-activated non-selective cation channel 1; Long transient receptor potential channel 4; LTrpC-4; LTrpC4; Melastatin-4; LTRPC4; TRPM4 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1214

• Cellular Location: Isoform 1: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus
• Tissue Location: Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TRPM4 blocking peptide

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 74715868
• NCBI GeneID: 54795
• UniProt Accession #: Q8TD43; Q7Z5D9; Q96L84; Q9NXV1; A2RU25
• Molecular Weight: 118,630 Da
• NCBI Official Full Name: Transient receptor potential cation channel subfamily M member 4
• NCBI Official Synonym Full Names: transient receptor potential cation channel subfamily M member 4
• NCBI Official Symbol: TRPM4
• NCBI Official Synonym Symbols: LTrpC4; PFHB1B; TRPM4B; hTRPM4
• NCBI Protein Information: transient receptor potential cation channel subfamily M member 4
• UniProt Protein Name: Transient receptor potential cation channel subfamily M member 4
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: TRPM4
• UniProt Synonym Gene Names: LTRPC4; hTRPM4; LTrpC-4; LTrpC4
• UniProt Entry Name: TRPM4_HUMAN

NCBI Description

The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016]

Uniprot Description

TRPM4: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Defects in TRPM4 are the cause of progressive familial heart block type 1B (PFHB1B). It is a cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrioventricular block causing syncope and sudden death. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: cell soma; cytosol; endoplasmic reticulum; Golgi apparatus; nucleoplasm; plasma membrane

Molecular Function: calcium activated cation channel activity; sodium channel activity

Biological Process: dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; negative regulation of bone mineralization; negative regulation of osteoblast differentiation; positive regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of heart rate; positive regulation of vasoconstriction; protein sumoylation; regulation of T cell cytokine production

Disease: Progressive Familial Heart Block, Type Ib