TRIM25 blocking peptide
TRIM25 Antibody (Center) Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]
Uniprot Description
TRIM25: a ubiquitous protein that mediates estrogen action in various target organs. Contains one RING-type zinc finger and one SPRY domain.
Protein type: Transcription factor; Ubiquitin ligase; Ligase; EC 6.3.2.n3; EC 6.3.2.19; Nuclear receptor co-regulator; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: protein binding; transcription factor activity; ubiquitin-protein ligase activity
Biological Process: activation of NF-kappaB transcription factor; bypass DNA synthesis; innate immune response; negative regulation of interferon type I production; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity; protein monoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of virion penetration into host cell; response to estrogen stimulus
Research Articles on TRIM25
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Product Notes
The TRIM25 trim25 (Catalog #AAA9222058) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TRIM25, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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