TRB3 blocking peptide

TRB3 Peptide

Cat. Num. AAA153831

• Gene Names: TRIB3; NIPK; SINK; TRB3; SKIP3; C20orf97
• Applications: Blocking (BL)
• Synonyms: TRB3; TRB3 Peptide; Tribbles homolog 3; tribbles pseudokinase 3; TRIB3; NIPK; SINK; SKIP3; C20orf97; TRB3 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 358

• Applicable Applications for TRB3 blocking peptide: Blocking (BL)
• Application Notes: TRB3 peptide is used for blocking the activity of TRB3 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 17 amino acid peptide near the center of human TRB3.
• Preparation and Storage: Store TRB3 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 31542265
• NCBI GeneID: 57761
• NCBI Accession #: NP_066981
• NCBI GenBank Nucleotide #: NM_021158.4
• UniProt Accession #: Q96RU7; Q53GU4; Q53ZW7; Q6I9Y9; Q8TAI6; Q9H5M8; Q9NUD2
• Molecular Weight: 39,578 Da
• NCBI Official Full Name: tribbles homolog 3 isoform 1
• NCBI Official Synonym Full Names: tribbles pseudokinase 3
• NCBI Official Symbol: TRIB3
• NCBI Official Synonym Symbols: NIPK; SINK; TRB3; SKIP3; C20orf97
• NCBI Protein Information: tribbles homolog 3; TRB-3; p65-interacting inhibitor of NF-kappaB; p65-interacting inhibitor of NF-kappa-B; neuronal cell death inducible putative kinase; neuronal cell death-inducible putative kinase
• UniProt Protein Name: Tribbles homolog 3
• Protein Family: Telomere repeat-binding factor
• UniProt Gene Name: TRIB3
• UniProt Synonym Gene Names: C20orf97; NIPK; SKIP3; TRB3; TRB-3
• UniProt Entry Name: TRIB3_HUMAN

NCBI Description

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

TRB3: a Ca(2)/calmodulin-dependent protein kinase of the Trbl family. Induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. May negatively regulate the cell survival kinase AKT1.

Protein type: Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; Trbl family

Chromosomal Location of Human Ortholog: 20p13-p12.2

Cellular Component: nucleoplasm; plasma membrane; cytosol; nucleus

Molecular Function: protein binding; protein kinase inhibitor activity; ubiquitin-protein ligase regulator activity; ubiquitin protein ligase binding; kinase activity; protein kinase binding; transcription corepressor activity; ATP binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of protein binding; nerve growth factor receptor signaling pathway; transcription, DNA-dependent; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; protein amino acid phosphorylation; cellular response to insulin stimulus; positive regulation of ubiquitin-protein ligase activity; regulation of MAP kinase activity; insulin receptor signaling pathway; innate immune response; negative regulation of protein kinase activity; negative regulation of transcription, DNA-dependent; negative regulation of fatty acid biosynthetic process