Tdgf1 blocking peptide

Tdgf1 Blocking Peptide (N-term)

Gene Names

Tdgf1; CR1; cripto

Synonyms

Tdgf1; Tdgf1 Blocking Peptide (N-term); Teratocarcinoma-derived growth factor; Cripto growth factor; Epidermal growth factor-like Cripto protein; Cripto; Tdgf1 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 37-50 of HUMAN Tdgf1

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

171

Cellular Location

Cell membrane; Lipid-anchor, GPI-anchor

Tissue Location

Expressed at low level in specific organs of the adult animal such as spleen, heart, lung and brain. During gastrulation, expressed in the forming mesoderm. In later stages of the developing heart, expression is restricted to the truncus arteriosus

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Tdgf1 blocking peptide

Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

NCBI and Uniprot Product Information

NCBI GI #

1706128

NCBI GeneID

21667

UniProt Accession #

P51865

Molecular Weight

18,754 Da

NCBI Official Full Name

Teratocarcinoma-derived growth factor

NCBI Official Synonym Full Names

teratocarcinoma-derived growth factor 1

NCBI Official Symbol

Tdgf1

NCBI Official Synonym Symbols

CR1; cripto

NCBI Protein Information

teratocarcinoma-derived growth factor

UniProt Protein Name

Teratocarcinoma-derived growth factor

Protein Family

Teratocarcinoma-derived growth factor

UniProt Gene Name

Tdgf1

UniProt Synonym Gene Names

Cripto

UniProt Entry Name

TDGF1_MOUSE

Uniprot Description

TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Protein type: Membrane protein, GPI anchor; Motility/polarity/chemotaxis; Membrane protein, peripheral; Cell adhesion; Cell cycle regulation

Cellular Component: apical plasma membrane; cell surface; cytoplasm; extracellular region; extracellular space; extrinsic to plasma membrane; Golgi apparatus; lipid raft; nucleus; perinuclear region of cytoplasm

Molecular Function: coreceptor activity; growth factor activity; protein binding; receptor binding; Wnt-protein binding

Biological Process: activation of MAPK activity; anterior/posterior axis specification; BMP signaling pathway; cardiac muscle cell differentiation; cell differentiation; cell migration during sprouting angiogenesis; determination of anterior/posterior axis, embryo; epidermal growth factor receptor signaling pathway; gastrulation; heart development; in utero embryonic development; morphogenesis of a branching structure; negative regulation of apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; peptidyl-serine phosphorylation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of fibroblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of signal transduction; vasculogenesis; Wnt receptor signaling pathway through beta-catenin

Research Articles on Tdgf1

1. Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-kappaB/receptor activator NF-kappaB ligand, and NF-kappaB signaling pathways.

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Product Notes

The Tdgf1 tdgf1 (Catalog #AAA9229673) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tdgf1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Tdgf1 blocking peptide