TAPBPL blocking peptide

TAPBPL Antibody (N-term) Blocking Peptide

• Gene Names: TAPBPL; TAPBPR; TAPBP-R
• Synonyms: TAPBPL; TAPBPL Antibody (N-term) Blocking Peptide; Tapasin-related protein; TAPASIN-R; TAP-binding protein-like; TAP-binding protein-related protein; TAPBP-R; Tapasin-like; TAPBPL blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 468

• Cellular Location: Cell membrane; Single-pass type I membrane protein Endoplasmic reticulum membrane; Single-pass type I membrane protein Microsome membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note: Mainly found in endoplasmic reticulum but a minority is found on the cell surface
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TAPBPL blocking peptide

Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression.

NCBI and Uniprot Product Information

• NCBI GI #: 296452847
• NCBI GeneID: 55080
• UniProt Accession #: Q9BX59; Q9NWB8
• Molecular Weight: 55,092 Da
• NCBI Official Full Name: Tapasin-related protein
• NCBI Official Synonym Full Names: TAP binding protein like
• NCBI Official Symbol: TAPBPL
• NCBI Official Synonym Symbols: TAPBPR; TAPBP-R
• NCBI Protein Information: tapasin-related protein
• UniProt Protein Name: Tapasin-related protein
• Protein Family: Tapasin-related protein
• UniProt Gene Name: TAPBPL
• UniProt Synonym Gene Names: TAPASIN-R; TAPBP-R
• UniProt Entry Name: TPSNR_HUMAN

NCBI Description

Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]

Uniprot Description

TAPBPL: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. {ECO:0000269|PubMed:23401559}. Induced by interferon gamma. {ECO:0000269|PubMed:23401559}. 7 isoforms of the human protein are produced by alternative splicing

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Molecular Function: protein complex binding

Biological Process: negative regulation of antigen processing and presentation of peptide antigen via MHC class I