Rabbit anti-Human TAPBPL Polyclonal Antibody | anti-TAPBPL antibody

TAPBPL Antibody

Cat. Num. AAA969871

• Gene Names: TAPBPL; TAPBPR; TAPBP-R
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%,Protein G purified
• Synonyms: TAPBPL; Polyclonal Antibody; TAPBPL Antibody; Tapasin-related protein; TAPASIN-R; TAP-binding protein-like; TAP-binding protein-related protein; TAPBP-R; Tapasin-like; anti-TAPBPL antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 468

• Applicable Applications for anti-TAPBPL antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen: Recombinant human Tapasin-related protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-138659 / sc-138660
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human thyroid tissue MBS969871 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney tissue MBS969871 at dilution 1:100)

Related Product Information for anti-TAPBPL antibody

Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression.

NCBI and Uniprot Product Information

• NCBI GI #: 157739930
• NCBI GeneID: 55080
• NCBI Accession #: NP_060479.3
• NCBI GenBank Nucleotide #: NM_018009.4
• UniProt Accession #: Q9BX59; Q9NWB8
• Molecular Weight: 55,092 Da
• NCBI Official Full Name: tapasin-related protein
• NCBI Official Synonym Full Names: TAP binding protein-like
• NCBI Official Symbol: TAPBPL
• NCBI Official Synonym Symbols: TAPBPR; TAPBP-R
• NCBI Protein Information: tapasin-related protein
• UniProt Protein Name: Tapasin-related protein
• Protein Family: Tapasin-related protein
• UniProt Gene Name: TAPBPL
• UniProt Synonym Gene Names: TAPASIN-R; TAPBP-R
• UniProt Entry Name: TPSNR_HUMAN

NCBI Description

Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]

Uniprot Description

TAPBPL: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. {ECO:0000269|PubMed:23401559}. Induced by interferon gamma. {ECO:0000269|PubMed:23401559}. 7 isoforms of the human protein are produced by alternative splicing

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: endoplasmic reticulum membrane; Golgi membrane; integral to membrane; plasma membrane

Molecular Function: protein complex binding

Biological Process: immune system process; negative regulation of antigen processing and presentation of peptide antigen via MHC class I