STAG1 blocking peptide

STAG1 Antibody (Center) Blocking Peptide

• Gene Names: STAG1; SA1; SCC3A
• Synonyms: STAG1; STAG1 Antibody (Center) Blocking Peptide; Cohesin subunit SA-1; SCC3 homolog 1; Stromal antigen 1; SA1; STAG1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1258

• Cellular Location: Nucleus. Chromosome. Chromosome, centromere. Note: Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for STAG1 blocking peptide

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

NCBI and Uniprot Product Information

• NCBI GI #: 209572720
• NCBI GeneID: 10274
• UniProt Accession #: Q8WVM7; O00539; Q6P275
• Molecular Weight: 140,090 Da
• NCBI Official Full Name: Cohesin subunit SA-1
• NCBI Official Synonym Full Names: stromal antigen 1
• NCBI Official Symbol: STAG1
• NCBI Official Synonym Symbols: SA1; SCC3A
• NCBI Protein Information: cohesin subunit SA-1
• UniProt Protein Name: Cohesin subunit SA-1
• Protein Family: Cofilin
• UniProt Gene Name: STAG1
• UniProt Synonym Gene Names: SA1
• UniProt Entry Name: STAG1_HUMAN

NCBI Description

This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]

Uniprot Description

STAG1: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Belongs to the SCC3 family.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 3q22.3

Cellular Component: chromatin; chromosome; chromosome, pericentric region; cytosol; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: protein sumoylation; sister chromatid cohesion