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Western Blot (WB) (CALCRL Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CALCRL antibody detected the CALCRL protein (arrow).)

Rabbit anti-Human, Mouse CALCRL Polyclonal Antibody | anti-CALCRL antibody

CALCRL, ID (CALCRL, CGRPR, Calcitonin gene-related peptide type 1 receptor, Calcitonin receptor-like receptor) (FITC)

Gene Names
CALCRL; CRLR; CGRPR
Reactivity
Human, Mouse
Applications
Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
CALCRL; Polyclonal Antibody; ID (CALCRL; CGRPR; Calcitonin gene-related peptide type 1 receptor; Calcitonin receptor-like receptor) (FITC); Calcitonin receptor-like receptor; anti-CALCRL antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Applicable Applications for anti-CALCRL antibody
Western Blot (WB), FLISA
Application Notes
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.
Immunogen
CALCRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339-367 amino acids from the Central region of human CALCRL.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(CALCRL Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CALCRL antibody detected the CALCRL protein (arrow).)

Western Blot (WB) (CALCRL Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CALCRL antibody detected the CALCRL protein (arrow).)

Western Blot (WB)

(CALCRL Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the CALCRL antibody detected the CALCRL protein (arrow).)

Western Blot (WB) (CALCRL Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the CALCRL antibody detected the CALCRL protein (arrow).)
Related Product Information for anti-CALCRL antibody
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Product Categories/Family for anti-CALCRL antibody
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Kuwasako, K., et al. Biochem. Biophys. Res. Commun. 392(3):380-385(2010). Chang, C.L., et al. J. Biol. Chem. 285(2):1075-1080(2010). Barwell, J., et al. Peptides 31(1):170-176(2010). Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
52,929 Da
NCBI Official Full Name
calcitonin gene-related peptide type 1 receptor
NCBI Official Synonym Full Names
calcitonin receptor-like
NCBI Official Symbol
CALCRL
NCBI Official Synonym Symbols
CRLR; CGRPR
NCBI Protein Information
calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; calcitonin receptor-like receptor
UniProt Protein Name
Calcitonin gene-related peptide type 1 receptor
UniProt Gene Name
CALCRL
UniProt Synonym Gene Names
CGRPR; CGRP type 1 receptor
UniProt Entry Name
CALRL_HUMAN

Uniprot Description

CALCRL: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3. Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family.

Protein type: Membrane protein, multi-pass; GPCR, family 2; Cell cycle regulation; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: endoplasmic reticulum; lysosome; integral to plasma membrane; plasma membrane; endosome

Molecular Function: G-protein coupled receptor activity; protein binding; calcitonin gene-related polypeptide receptor activity; adrenomedullin receptor activity; protein transporter activity; calcitonin receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; protein transport; regulation of muscle contraction; calcium ion transport; receptor internalization; positive regulation of smooth muscle cell proliferation; heart development; negative regulation of inflammatory response; positive regulation of cAMP biosynthetic process; cAMP biosynthetic process; angiogenesis; G-protein signaling, adenylate cyclase activating pathway

Research Articles on CALCRL

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Product Notes

The CALCRL calcrl (Catalog #AAA6280521) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CALCRL, ID (CALCRL, CGRPR, Calcitonin gene-related peptide type 1 receptor, Calcitonin receptor-like receptor) (FITC) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CALCRL can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:100-500 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the CALCRL calcrl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CALCRL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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