SRGAP2 blocking peptide

SRGAP2 Blocking Peptide (C-term)

• Gene Names: SRGAP2; FNBP2; SRGAP3; SRGAP2A; ARHGAP34
• Synonyms: SRGAP2; SRGAP2 Blocking Peptide (C-term); SLIT-ROBO Rho GTPase-activating protein 2; srGAP2; Formin-binding protein 2; Rho GTPase-activating protein 34; ARHGAP34; FNBP2; KIAA0456; SRGAP2A; SRGAP2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 997-1010 of HUMAN SRGAP2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1071

• Cellular Location: Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, postsynaptic cell membrane. Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome Nucleus. Cytoplasm. Note: Recruited to actin-rich phagosomes during phagocytosis. Translocates from nucleus to cytoplasm during development.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SRGAP2 blocking peptide

RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

NCBI and Uniprot Product Information

• NCBI GI #: 48427907
• NCBI GeneID: 23380
• UniProt Accession #: O75044
• Molecular Weight: 120,881 Da
• NCBI Official Full Name: SLIT-ROBO Rho GTPase-activating protein 2
• NCBI Official Synonym Full Names: SLIT-ROBO Rho GTPase activating protein 2
• NCBI Official Symbol: SRGAP2
• NCBI Official Synonym Symbols: FNBP2; SRGAP3; SRGAP2A; ARHGAP34
• NCBI Protein Information: SLIT-ROBO Rho GTPase-activating protein 2
• UniProt Protein Name: SLIT-ROBO Rho GTPase-activating protein 2
• Protein Family: SLIT-ROBO Rho GTPase-activating protein
• UniProt Gene Name: SRGAP2
• UniProt Synonym Gene Names: ARHGAP34; FNBP2; KIAA0456; SRGAP2A; srGAP2
• UniProt Entry Name: SRGP2_HUMAN

NCBI Description

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]

Uniprot Description

SRGAP2: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).

Protein type: GAPs; Motility/polarity/chemotaxis; Mitochondrial; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytoplasm; cytosol; lamellipodium; phagocytic vesicle; plasma membrane; postsynaptic density; postsynaptic membrane

Molecular Function: GTPase activator activity; protein binding; protein homodimerization activity; Rac GTPase binding

Biological Process: actin filament severing; cell proliferation; extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration; filopodium formation; neurite morphogenesis; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction