Western Blot (WB)
(All lanes : Anti-SRGAP2 Antibody (C-term) at 1:2000 dilutionLane 1: DU145 whole cell lysateLane 2: human cerebellum lysateLane 3: mouse brain lysateLane 4: MCF-7 whole cell lysateLane 5: SH-SY5Y whole cell lysateLane 6: SW480 whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 121 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Rabbit SRGAP2 Polyclonal Antibody | anti-SRGAP2 antibody
SRGAP2 Antibody (C-term)
Gene Names
SRGAP2; FNBP2; SRGAP3; SRGAP2A; ARHGAP34
Reactivity
Human, MousePredicted: Rat
Applications
Western Blot, ELISA
Synonyms
SRGAP2; Polyclonal Antibody; SRGAP2 Antibody (C-term); SLIT-ROBO Rho GTPase-activating protein 2; srGAP2; Formin-binding protein 2; Rho GTPase-activating protein 34; ARHGAP34; FNBP2; KIAA0456; SRGAP2A; anti-SRGAP2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Predicted: Rat
Predicted: Rat
Clonality
Polyclonal
Isotype
Ig
Specificity
This SRGAP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1040-1071amino acids from the C-terminal region of human SRGAP2.
Sequence Length
1070
Applicable Applications for anti-SRGAP2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:2000
Antigen Source
Human
Antigen Region
1040-1071
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(All lanes : Anti-SRGAP2 Antibody (C-term) at 1:2000 dilutionLane 1: DU145 whole cell lysateLane 2: human cerebellum lysateLane 3: mouse brain lysateLane 4: MCF-7 whole cell lysateLane 5: SH-SY5Y whole cell lysateLane 6: SW480 whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 121 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Western Blot (WB)
(All lanes : Anti-SRGAP2 Antibody (C-term) at 1:2000 dilutionLane 1: DU145 whole cell lysateLane 2: human cerebellum lysateLane 3: mouse brain lysateLane 4: MCF-7 whole cell lysateLane 5: SH-SY5Y whole cell lysateLane 6: SW480 whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 121 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Related Product Information for anti-SRGAP2 antibody
Description: Purified Rabbit Polyclonal Antibody (Pab)
Background: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.
Background: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.
Product Categories/Family for anti-SRGAP2 antibody
References
Seki N.,et al.DNA Res. 4:345-349(1997). Wong K.,et al.Cell 107:209-221(2001). Olsen J.V.,et al.Cell 127:635-648(2006). Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
120871
NCBI Official Full Name
SLIT-ROBO Rho GTPase-activating protein 2 isoform c
NCBI Official Synonym Full Names
SLIT-ROBO Rho GTPase activating protein 2
NCBI Official Symbol
SRGAP2
NCBI Official Synonym Symbols
FNBP2; SRGAP3; SRGAP2A; ARHGAP34
NCBI Protein Information
SLIT-ROBO Rho GTPase-activating protein 2
UniProt Protein Name
SLIT-ROBO Rho GTPase-activating protein 2
Protein Family
UniProt Gene Name
SRGAP2
UniProt Synonym Gene Names
ARHGAP34; FNBP2; KIAA0456; SRGAP2A; srGAP2
UniProt Entry Name
SRGP2_HUMAN
NCBI Description
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]
Research Articles on SRGAP2
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Product Notes
The SRGAP2 srgap2 (Catalog #AAA9232129) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SRGAP2 Antibody (C-term) reacts with Human, Mouse Predicted: Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SRGAP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:2000. Researchers should empirically determine the suitability of the SRGAP2 srgap2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SRGAP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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