SMC2 blocking peptide

SMC2 Antibody (C-term) Blocking Peptide

• Gene Names: SMC2; CAPE; CAP-E; SMC-2; SMC2L1
• Synonyms: SMC2; SMC2 Antibody (C-term) Blocking Peptide; Structural maintenance of chromosomes protein 2; SMC protein 2; SMC-2; Chromosome-associated protein E; hCAP-E; XCAP-E homolog; CAPE; SMC2L1; SMC2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human SMC2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1197

• Cellular Location: Nucleus. Cytoplasm. Chromosome. Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SMC2 blocking peptide

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

NCBI and Uniprot Product Information

• NCBI GI #: 215273886
• NCBI GeneID: 10592
• UniProt Accession #: O95347; Q6IEE0; Q9P1P2
• Molecular Weight: 124,926 Da
• NCBI Official Full Name: Structural maintenance of chromosomes protein 2
• NCBI Official Synonym Full Names: structural maintenance of chromosomes 2
• NCBI Official Symbol: SMC2
• NCBI Official Synonym Symbols: CAPE; CAP-E; SMC-2; SMC2L1
• NCBI Protein Information: structural maintenance of chromosomes protein 2
• UniProt Protein Name: Structural maintenance of chromosomes protein 2
• UniProt Gene Name: SMC2
• UniProt Synonym Gene Names: CAPE; SMC2L1; SMC protein 2; SMC-2; hCAP-E
• UniProt Entry Name: SMC2_HUMAN

Uniprot Description

SMC2L1: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Belongs to the SMC family. SMC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: condensed chromosome; condensin complex; cytoplasm; cytosol; nuclear chromosome; nucleolus; nucleoplasm; nucleus

Molecular Function: protein binding; protein heterodimerization activity

Biological Process: mitotic chromosome condensation