SLC9A1 blocking peptide

SLC9A1 Blocking Peptide

Cat. Num. AAA9628953

• Gene Names: SLC9A1; APNH; NHE1; NHE-1; PPP1R143
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: SLC9A1; SLC9A1 Blocking Peptide; amiloride-sensitive; APNH; APNH1; FLJ42224; Na Li countertransporter; Na(+)/H(+) antiporter; Na(+)/H(+) exchanger 1; Na+ H+ antiporter amiloride-sensitive; Na+ H+ antiporter; Na+ H+ exchanger 1; NHE-1; NHE1; OTTHUMP00000004468; SL9A1_HUMAN; Sodium hydrogen exchanger 1; Sodium/hydrogen exchanger 1; solute carrier family 9; Solute carrier family 9 member 1; Solute carrier family 9 sodium hydrogen exchanger isoform 1 antiporter Na+ H+ amiloride sensitive; Solute carrier family 9 subfamily A (NHE1 cation proton antiporter 1) member 1; Solute carrier family 9 subfamily A member 1; SLC9A1 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for SLC9A1 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SLC9A1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 27777632
• NCBI GeneID: 6548
• NCBI Accession #: NP_003038.2
• NCBI GenBank Nucleotide #: NM_003047.4
• UniProt Accession #: P19634; Q96EM2; B1ALD6; D3DPL4
• Molecular Weight: 61,013 Da
• NCBI Official Full Name: sodium/hydrogen exchanger 1
• NCBI Official Synonym Full Names: solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
• NCBI Official Symbol: SLC9A1
• NCBI Official Synonym Symbols: APNH; NHE1; NHE-1; PPP1R143
• NCBI Protein Information: sodium/hydrogen exchanger 1; Na(+)/H(+) exchanger 1; Na-Li countertransporter; protein phosphatase 1, regulatory subunit 143; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9
• UniProt Protein Name: Sodium/hydrogen exchanger 1
• Protein Family: Sodium/hydrogen exchanger
• UniProt Gene Name: SLC9A1
• UniProt Synonym Gene Names: APNH1; NHE1; NHE-1
• UniProt Entry Name: SL9A1_HUMAN

NCBI Description

This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]

Uniprot Description

NHE1: sodium/hydrogen exchanger 1. Belongs to the Na(+)/H(+) exchanger family. Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient.

Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Motility/polarity/chemotaxis; Transporter

Chromosomal Location of Human Ortholog: 1p36.1-p35

Cellular Component: endoplasmic reticulum membrane; focal adhesion; cell surface; mitochondrion; basolateral plasma membrane; endoplasmic reticulum; integral to plasma membrane; T-tubule; integral to membrane; lipid raft; nucleoplasm; perinuclear region of cytoplasm; lamellipodium; apical plasma membrane; cytoplasm; plasma membrane

Molecular Function: protein binding, bridging; calmodulin binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein complex scaffold; solute:hydrogen antiporter activity; calcium-dependent protein binding; sodium:hydrogen antiporter activity; protein phosphatase 2B binding

Biological Process: positive regulation of NFAT protein import into nucleus; glycosaminoglycan metabolic process; pathogenesis; cardiac muscle cell differentiation; hyaluronan catabolic process; regulation of pH; positive regulation of action potential; cell growth; transmembrane transport; response to drug; cellular sodium ion homeostasis; cell migration; maintenance of cell polarity; positive regulation of cell growth; protein oligomerization; cellular response to insulin stimulus; regulation of stress fiber formation; carbohydrate metabolic process; regulation of focal adhesion formation; regulation of intracellular pH; ion transport; positive regulation of transcription from RNA polymerase II promoter; response to acidity; regulation of sensory perception of pain; hyaluronan metabolic process; negative regulation of apoptosis

Disease: Lichtenstein-knorr Syndrome