SIT1 blocking peptide

SIT1 Antibody (C-term) Blocking Peptide

• Gene Names: SIT1; SIT; SIT-R
• Synonyms: SIT1; SIT1 Antibody (C-term) Blocking Peptide; Signaling threshold-regulating transmembrane adapter 1; SHP2-interacting transmembrane adapter protein; Suppression-inducing transmembrane adapter 1; gp30/40; SIT; SIT1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 196

• Cellular Location: Cell membrane; Single-pass type I membrane protein
• Tissue Location: Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SIT1 blocking peptide

Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells. Involved in positive selection of T-cells.

NCBI and Uniprot Product Information

• NCBI GI #: 74753488
• NCBI GeneID: 27240
• UniProt Accession #: Q9Y3P8; B2RBP9
• Molecular Weight: 21,126 Da
• NCBI Official Full Name: Signaling threshold-regulating transmembrane adapter 1
• NCBI Official Synonym Full Names: signaling threshold regulating transmembrane adaptor 1
• NCBI Official Symbol: SIT1
• NCBI Official Synonym Symbols: SIT; SIT-R
• NCBI Protein Information: signaling threshold-regulating transmembrane adapter 1
• UniProt Protein Name: Signaling threshold-regulating transmembrane adapter 1
• Protein Family: Signaling threshold-regulating transmembrane adapter
• UniProt Gene Name: SIT1
• UniProt Synonym Gene Names: SIT
• UniProt Entry Name: SIT1_HUMAN

Uniprot Description

SIT: a low molecular weight transmembrane adaptor protein. A disulfide-linked homodimer. Expressed in lymphocytes. Following phosphorylation by Src and possibly Tec kinases, recruits the SH2 domain-containing tyrosine phosphatase SHP2 via an immunoreceptor tyrosine-based inhibition motif (ITIM).

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9p13-p12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: kinase binding; protein binding; SH2 domain binding

Biological Process: regulation of T cell activation