SIGLEC10 blocking peptide

SIGLEC10 Antibody (C-term) Blocking Peptide

• Gene Names: SIGLEC10; SLG2; PRO940; SIGLEC-10
• Synonyms: SIGLEC10; SIGLEC10 Antibody (C-term) Blocking Peptide; Sialic acid-binding Ig-like lectin 10; Siglec-10; Siglec-like protein 2; SLG2; SIGLEC10 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human SIGLEC10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 697

• Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cell membrane; Single-pass type I membrane protein Isoform 5: Secreted.
• Tissue Location: Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation) Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SIGLEC10 blocking peptide

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

NCBI and Uniprot Product Information

• NCBI GI #: 118572721
• NCBI GeneID: 89790
• UniProt Accession #: Q96LC7; Q3MIR5; Q6UXI8; Q96G54; Q96LC8; A8K1I5; A8K3C7; C9JJ33; C9JM10; F8W917
• Molecular Weight: 57,486 Da
• NCBI Official Full Name: Sialic acid-binding Ig-like lectin 10
• NCBI Official Synonym Full Names: sialic acid binding Ig like lectin 10
• NCBI Official Symbol: SIGLEC10
• NCBI Official Synonym Symbols: SLG2; PRO940; SIGLEC-10
• NCBI Protein Information: sialic acid-binding Ig-like lectin 10
• UniProt Protein Name: Sialic acid-binding Ig-like lectin 10
• Protein Family: Sialic acid-binding Ig-like lectin
• UniProt Gene Name: SIGLEC10
• UniProt Synonym Gene Names: SLG2; Siglec-10
• UniProt Entry Name: SIG10_HUMAN

NCBI Description

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

Uniprot Description

Siglec-10: a cell surface protein belonging to the immunoglobulin superfamily and the SIGLEC (sialic acid binding Ig-like lectin) family. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Five alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3