SH2D2A blocking peptide

SH2D2A Antibody (Center) Blocking peptide

• Gene Names: SH2D2A; SCAP; TSAD; VRAP; F2771
• Synonyms: SH2D2A; SH2D2A Antibody (Center) Blocking peptide; SH2 domain-containing protein 2A; SH2 domain-containing adapter protein; T cell-specific adapter protein; TSAd; VEGF receptor-associated protein; SCAP; TSAD; VRAP; SH2D2A blocking peptide

• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 389

• Cellular Location: Cytoplasm.
• Tissue Location: Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SH2D2A blocking peptide

Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.

NCBI and Uniprot Product Information

• NCBI GI #: 239787750
• NCBI GeneID: 9047
• NCBI Accession #: NP_003966.2
• NCBI GenBank Nucleotide #: NM_003975.3
• UniProt Accession #: Q9NP31; O43817; Q5UBZ1; Q5VZS4; Q5VZS5; Q9UPA7
• Molecular Weight: 40,954 Da
• NCBI Official Full Name: SH2 domain-containing protein 2A isoform 2
• NCBI Official Synonym Full Names: SH2 domain containing 2A
• NCBI Official Symbol: SH2D2A
• NCBI Official Synonym Symbols: SCAP; TSAD; VRAP; F2771
• NCBI Protein Information: SH2 domain-containing protein 2A
• UniProt Protein Name: SH2 domain-containing protein 2A
• Protein Family: SH2 domain-containing protein
• UniProt Gene Name: SH2D2A
• UniProt Synonym Gene Names: SCAP; TSAD; VRAP; TSAd
• UniProt Entry Name: SH22A_HUMAN

NCBI Description

This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Description

TSAd: an adaptor protein that may facilitate and regulate interaction of KDR with effector proteins important to endothelial cell survival and proliferation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway in T cells. Could also play an important role in normal and pathological angiogenesis.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity

Biological Process: signal transduction; vascular endothelial growth factor receptor signaling pathway