SENP2 blocking peptide

SENP2 Antibody (C-term) Blocking Peptide

• Gene Names: SENP2; AXAM2; SMT3IP2
• Synonyms: SENP2; SENP2 Antibody (C-term) Blocking Peptide; Sentrin-specific protease 2; Axam2; SMT3-specific isopeptidase 2; Smt3ip2; Sentrin/SUMO-specific protease SENP2; KIAA1331; SENP2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human SENP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 589

• Cellular Location: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side Cytoplasm. Note: Shuttles between cytoplasm and nucleus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SENP2 blocking peptide

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1.

NCBI and Uniprot Product Information

• NCBI GI #: 143811458
• NCBI GeneID: 59343
• UniProt Accession #: Q9HC62; Q8IW97; Q96SR2; Q9P2L5; B4DQ42
• Molecular Weight: 66,358 Da
• NCBI Official Full Name: Sentrin-specific protease 2
• NCBI Official Synonym Full Names: SUMO1/sentrin/SMT3 specific peptidase 2
• NCBI Official Symbol: SENP2
• NCBI Official Synonym Symbols: AXAM2; SMT3IP2
• NCBI Protein Information: sentrin-specific protease 2
• UniProt Protein Name: Sentrin-specific protease 2
• Protein Family: Sentrin-specific protease
• UniProt Gene Name: SENP2
• UniProt Synonym Gene Names: KIAA1331; Smt3ip2
• UniProt Entry Name: SENP2_HUMAN

NCBI Description

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

Uniprot Description

SENP2: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Belongs to the peptidase C48 family.

Protein type: Protease; EC 3.4.22.68

Chromosomal Location of Human Ortholog: 3q27.2

Cellular Component: nuclear pore; nucleoplasm; PML body

Molecular Function: endopeptidase activity; protein binding; SUMO-specific protease activity

Biological Process: fat cell differentiation; negative regulation of protein ubiquitination; positive regulation of protein ubiquitination; protein destabilization; protein desumoylation; protein sumoylation