Rabbit anti-Human, Mouse SENP2 Polyclonal Antibody | anti-SENP2 antibody

SENP2, CT (Sentrin-specific Protease 2, Sentrin/SUMO-specific Protease SENP2, SMT3-Specific Isopeptidase 2, Smt3ip2, Axam2, KIAA1331)

Cat. Num. AAA624528

• Gene Names: SENP2; AXAM2; SMT3IP2; KIAA1331; DKFZp762A2316
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: SENP2; Polyclonal Antibody; CT (Sentrin-specific Protease 2; Sentrin/SUMO-specific Protease SENP2; SMT3-Specific Isopeptidase 2; Smt3ip2; Axam2; KIAA1331); Anti -SENP2; anti-SENP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SENP2. Species Crossreactivity: mouse.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-SENP2 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot, and Immunohistochemistry.; Dilution: ELISA: 1:1,000; Western Blot: 1:100-1:500; Immunohistochemistry: 1:50-1:100
• Immunogen: Synthetic peptide selected from the C-terminal region of human SENP2 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(The SENP2 C-term polyclonal antibody is used in Western blot to detect SENP2 in mouse heart tissue lysate.)

Western Blot (WB)

(Western blot analysis of anti-SENP2 Antibody (C-term) in HL60 cell line lysates (35ug/lane). SENP2(arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)

Related Product Information for anti-SENP2 antibody

SUMO is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1, SUMO2, and SUMO3 into the conjugatable mature forms and catalyze the deconjugation of these same SUMO proteins from their targeted substrates. SENP2 may also down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.

Product Categories/Family for anti-SENP2 antibody

Antibodies; Abs to Ubiquitin

NCBI and Uniprot Product Information

• NCBI GI #: 54607091
• NCBI GeneID: 59343
• NCBI Accession #: NP_067640.2
• NCBI GenBank Nucleotide #: NM_021627.2
• UniProt Accession #: Q9HC62; Q8IW97; Q96SR2; Q9P2L5
• Molecular Weight: 67,855 Da
• NCBI Official Full Name: sentrin-specific protease 2
• NCBI Official Synonym Full Names: SUMO1/sentrin/SMT3 specific peptidase 2
• NCBI Official Symbol: SENP2
• NCBI Official Synonym Symbols: AXAM2; SMT3IP2; KIAA1331; DKFZp762A2316
• NCBI Protein Information: sentrin-specific protease 2; OTTHUMP00000210348; SMT3-specific isopeptidase 2; sentrin/SUMO-specific protease SENP2; SUMO1/sentrin/SMT3 specific protease 2
• UniProt Protein Name: Sentrin-specific protease 2
• Protein Family: Sentrin-specific protease
• UniProt Gene Name: SENP2
• UniProt Synonym Gene Names: KIAA1331
• UniProt Entry Name: SENP2_HUMAN

NCBI Description

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM]

Uniprot Description

SENP2: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Belongs to the peptidase C48 family.

Protein type: EC 3.4.22.68; Protease

Chromosomal Location of Human Ortholog: 3q27.2

Cellular Component: nucleoplasm; PML body; nuclear membrane; nuclear pore; cytoplasmic vesicle

Molecular Function: protein domain specific binding; protein binding; SUMO-specific protease activity

Biological Process: protein desumoylation; mRNA transport; Wnt receptor signaling pathway; heart development; regulation of Wnt receptor signaling pathway; dorsal/ventral axis specification; post-translational protein modification; proteolysis; regulation of DNA endoreduplication; negative regulation of DNA damage response, signal transduction by p53 class mediator; protein transport; protein sumoylation; cellular protein metabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of protein binding