SDCBP blocking peptide

SDCBP Blocking Peptide (N-term)

• Gene Names: SDCBP; ST1; MDA9; SYCL; MDA-9; TACIP18
• Synonyms: SDCBP; SDCBP Blocking Peptide (N-term); Syntenin-1; Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1; MDA9; SYCL; SDCBP blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 7-20 of HUMAN SDCBP
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 298

• Cellular Location: Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Note: Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum Colocalized with actin stress fibers. Also found in the nucleus Identified by mass spectrometry in melanosome fractions from stage I to stage IV
• Tissue Location: Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SDCBP blocking peptide

Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 56243522
• NCBI GeneID: 6386
• NCBI Accession #: NP_005616.2
• NCBI GenBank Nucleotide #: NM_005625.3
• UniProt Accession #: O00560; O00173; O43391; Q14CP2; B2R5Q7; B4DUH3; B7ZLN2
• Molecular Weight: 31,762 Da
• NCBI Official Full Name: syntenin-1 isoform 1
• NCBI Official Synonym Full Names: syndecan binding protein
• NCBI Official Symbol: SDCBP
• NCBI Official Synonym Symbols: ST1; MDA9; SYCL; MDA-9; TACIP18
• NCBI Protein Information: syntenin-1
• UniProt Protein Name: Syntenin-1
• Protein Family: Syntenin
• UniProt Gene Name: SDCBP
• UniProt Synonym Gene Names: MDA9; SYCL; MDA-9; TACIP18
• UniProt Entry Name: SDCB1_HUMAN

NCBI Description

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

syntenin: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Vesicle; Cytokine; Cell adhesion; Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8q12

Cellular Component: cytoplasm; cytosol; extracellular space; interleukin-5 receptor complex; lipid raft; plasma membrane

Molecular Function: frizzled binding; identical protein binding; interleukin-5 receptor binding; protein binding; protein heterodimerization activity; protein N-terminus binding; syndecan binding

Biological Process: ephrin receptor signaling pathway; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of receptor internalization; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of JNK cascade; positive regulation of phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of mitotic cell cycle