SCYL1 blocking peptide

SCYL1 Antibody (N-term) Blocking Peptide

• Gene Names: SCYL1; GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019; SCAR21
• Synonyms: SCYL1; SCYL1 Antibody (N-term) Blocking Peptide; N-terminal kinase-like protein; Coated vesicle-associated kinase of 90 kDa; SCY1-like protein 1; Telomerase regulation-associated protein; Telomerase transcriptional element-interacting factor; Teratoma-associated tyrosine kinase; CVAK90; GKLP; NTKL; TAPK; TEIF; TRAP; SCYL1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human SCYL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 808

• Cellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note: Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner Isoform 2: Cytoplasm. Note: Cytoplasmic throughout the cell cycle Isoform 6: Nucleus
• Tissue Location: Ubiquitous..
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SCYL1 blocking peptide

Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro.

NCBI and Uniprot Product Information

• NCBI GI #: 74762671
• NCBI GeneID: 57410
• UniProt Accession #: Q96KG9; Q96G50; Q96KG8; Q96KH1; Q9HAW5; Q9HBL3; Q9NR53; A6NJF1
• Molecular Weight: 86,371 Da
• NCBI Official Full Name: N-terminal kinase-like protein
• NCBI Official Synonym Full Names: SCY1 like pseudokinase 1
• NCBI Official Symbol: SCYL1
• NCBI Official Synonym Symbols: GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019; SCAR21
• NCBI Protein Information: N-terminal kinase-like protein
• UniProt Protein Name: N-terminal kinase-like protein
• Protein Family: N-terminal kinase-like protein
• UniProt Gene Name: SCYL1
• UniProt Synonym Gene Names: CVAK90; GKLP; NTKL; TAPK; TEIF; TRAP
• UniProt Entry Name: NTKL_HUMAN

NCBI Description

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SCYL1: Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro. Belongs to the protein kinase superfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; SCY1 family

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cis-Golgi network; COPI vesicle coat; cytoplasm; ER-Golgi intermediate compartment; Golgi apparatus; membrane

Biological Process: retrograde vesicle-mediated transport, Golgi to ER