SARNP blocking peptide

SARNP Peptide

Cat. Num. AAA3005763

• Gene Names: SARNP; HCC1; THO1; CIP29; HSPC316
• Applications: Blocking
• Purity: Synthetic peptide SARNP. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: SARNP; SARNP Peptide; SAP domain-containing ribonucleoprotein; Cytokine-induced protein of 29 kDa; Nuclear protein Hcc-1; Proliferation-associated cytokine-inducible protein CIP29; Synonyms: HCC1; ORF Names: HSPC316; SARNP blocking peptide

• Specificity: This peptide can be used with studies using MBS3005762 SARNP pAb.
• Purity/Purification: Synthetic peptide SARNP. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 210

• Applicable Applications for SARNP blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for SARNP blocking peptide

SARNP (SAP domain-containing ribonucleoprotein), also known as CIP29 (Cytokine-induced protein of 29 kDa) and HCC1 (Nuclear protein Hcc-1), is a 210 amino acid nuclear protein whose expression is upregulated by erythropoietin. Induction of SARNP expression is associated with cell cycle progression and apoptosis. This transcription factor binds both single stranded (ss) and double stranded (ds) DNA, though it has higher affinity for ssDNA. SARNP is expressed at low levels in pancreas, spleen, testis, liver, kidney, heart and thymus, and is found to be expressed at higher levels in pancreatic adenocarcinoma and hepatocellular carcinoma.

NCBI and Uniprot Product Information

• NCBI GI #: 32129199
• NCBI GeneID: 84324
• NCBI Accession #: NP_149073.1
• NCBI GenBank Nucleotide #: NP_149073.1
• UniProt Accession #: P82979
• NCBI Official Full Name: SAP domain-containing ribonucleoprotein
• NCBI Official Synonym Full Names: SAP domain containing ribonucleoprotein
• NCBI Official Symbol: SARNP
• NCBI Official Synonym Symbols: HCC1; THO1; CIP29; HSPC316
• NCBI Protein Information: SAP domain-containing ribonucleoprotein
• UniProt Protein Name: SAP domain-containing ribonucleoprotein
• Protein Family: SAP domain-containing ribonucleoprotein
• UniProt Gene Name: SARNP
• UniProt Synonym Gene Names: HCC1
• UniProt Entry Name: SARNP_HUMAN

NCBI Description

This gene encodes a protein that is upregulated in response to various cytokines. The encoded protein may play a role in cell cycle progression. A translocation between this gene and the myeloid/lymphoid leukemia gene, resulting in expression of a chimeric protein, has been associated with acute myelomonocytic leukemia. Pseudogenes exist on chromosomes 7 and 8. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Uniprot Description

CIP29: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nuclear speck; nucleus

Molecular Function: DNA binding

Biological Process: regulation of translation; mRNA export from nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent