Ror2 blocking peptide

Mouse Ror2 Blocking Peptide (C-term)

• Gene Names: Ror2; mRor2; Ntrkr2
• Synonyms: Ror2; Mouse Ror2 Blocking Peptide (C-term); Tyrosine-protein kinase transmembrane receptor ROR2; mROR2; Neurotrophic tyrosine kinase; receptor-related 2; Ror2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 756-770 of HUMAN Ror2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 944

• Cellular Location: Cell membrane; Single-pass type I membrane protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Ror2 blocking peptide

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 341941988
• NCBI GeneID: 26564
• UniProt Accession #: Q9Z138; E9QKB3
• Molecular Weight: 105,005 Da
• NCBI Official Full Name: Tyrosine-protein kinase transmembrane receptor ROR2
• NCBI Official Synonym Full Names: receptor tyrosine kinase-like orphan receptor 2
• NCBI Official Symbol: Ror2
• NCBI Official Synonym Symbols: mRor2; Ntrkr2
• NCBI Protein Information: tyrosine-protein kinase transmembrane receptor ROR2
• UniProt Protein Name: Tyrosine-protein kinase transmembrane receptor ROR2
• UniProt Gene Name: Ror2
• UniProt Synonym Gene Names: mROR2
• UniProt Entry Name: ROR2_MOUSE

Uniprot Description

ROR2: a receptor tyrosine kinase of the ROR family. May be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.

Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Ror family

Cellular Component: integral to plasma membrane

Molecular Function: frizzled binding; protein binding; transmembrane receptor protein tyrosine kinase activity; Wnt-protein binding

Biological Process: BMP signaling pathway; cartilage condensation; cell differentiation; cell fate commitment; embryonic digit morphogenesis; embryonic genitalia morphogenesis; inner ear morphogenesis; JNK cascade; negative regulation of cell proliferation; positive regulation of cell migration; positive regulation of transcription, DNA-dependent; skeletal development; smoothened signaling pathway; somitogenesis; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway