RGS5 blocking peptide

RGS5 Blocking Peptide

Cat. Num. AAA9624588

• Gene Names: RGS5; MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: RGS5; RGS5 Blocking Peptide; MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129; Regulator of G Protein Signalling 5; Regulator of G-protein signaling 5; RGS 5; RGS5_HUMAN; RGS5 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for RGS5 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RGS5 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 305855068
• NCBI GeneID: 8490
• NCBI Accession #: NP_001182232.1
• NCBI GenBank Nucleotide #: NM_001195303.2
• UniProt Accession #: O15539; Q53XA9; Q599J0; E9PMP5
• Molecular Weight: 20,946 Da
• NCBI Official Full Name: regulator of G-protein signaling 5 isoform 2
• NCBI Official Synonym Full Names: regulator of G-protein signaling 5
• NCBI Official Symbol: RGS5
• NCBI Official Synonym Symbols: MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
• NCBI Protein Information: regulator of G-protein signaling 5
• UniProt Protein Name: Regulator of G-protein signaling 5
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS5
• UniProt Synonym Gene Names: RGS5
• UniProt Entry Name: RGS5_HUMAN

NCBI Description

This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]

Uniprot Description

RGS5: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, RGS

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: cytoplasm; plasma membrane

Molecular Function: GTPase activator activity

Biological Process: signal transduction; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity

Disease: Hypertension, Essential