RGS3 blocking peptide

RGS3 Blocking Peptide (N-Term)

• Gene Names: RGS3; C2PA; RGP3
• Synonyms: RGS3; RGS3 Blocking Peptide (N-Term); Regulator of G-protein signaling 3; RGP3; RGS3 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 293-307 of HUMAN RGS3
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1198

• Cellular Location: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein Note: Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RGS3 blocking peptide

Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases.

NCBI and Uniprot Product Information

• NCBI GI #: 67477383
• NCBI GeneID: 5998
• UniProt Accession #: P49796; Q5VXB8; Q5VXC1; Q5VZ05; Q5VZ06; Q6ZRM5; Q8IUQ1; Q8NC47; Q8NFN4; A6NHA0; A8K0V1; B3KUB2
• Molecular Weight: 66,478 Da
• NCBI Official Full Name: Regulator of G-protein signaling 3
• NCBI Official Synonym Full Names: regulator of G-protein signaling 3
• NCBI Official Symbol: RGS3
• NCBI Official Synonym Symbols: C2PA; RGP3
• NCBI Protein Information: regulator of G-protein signaling 3
• UniProt Protein Name: Regulator of G-protein signaling 3
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS3
• UniProt Synonym Gene Names: RGP3; RGS3
• UniProt Entry Name: RGS3_HUMAN

NCBI Description

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]

Uniprot Description

RGS3: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, RGS

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane

Molecular Function: GTPase activator activity; protein binding

Biological Process: inactivation of MAPK activity; regulation of G-protein coupled receptor protein signaling pathway