RAB1B blocking peptide

RAB1B Antibody (C-term) Blocking peptide

• Synonyms: RAB1B; RAB1B Antibody (C-term) Blocking peptide; Ras-related protein Rab-1B; RAB1B blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of RAB1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 201

• Cellular Location: Cytoplasm. Membrane; Lipid-anchor; Cytoplasmic side. Preautophagosomal structure membrane; Lipid-anchor; Cytoplasmic side. Note: Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RAB1B blocking peptide

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.

NCBI and Uniprot Product Information

• NCBI GI #: 23396834
• NCBI GeneID: 81876
• UniProt Accession #: Q9H0U4; A8K7S1
• Molecular Weight: 22,171 Da
• NCBI Official Full Name: Ras-related protein Rab-1B
• NCBI Official Synonym Full Names: RAB1B, member RAS oncogene family
• NCBI Official Symbol: RAB1B
• NCBI Protein Information: ras-related protein Rab-1B
• UniProt Protein Name: Ras-related protein Rab-1B
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB1B
• UniProt Entry Name: RAB1B_HUMAN

NCBI Description

Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]

Uniprot Description

RAB1B: Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein; G protein, monomeric, Rab; G protein, monomeric

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; pre-autophagosomal structure membrane; transport vesicle

Molecular Function: GTP binding; protein binding

Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to ER; virus assembly