RAB11B blocking peptide

RAB11B Antibody (C-term) Blocking peptide

• Gene Names: RAB11B; H-YPT3
• Synonyms: RAB11B; RAB11B Antibody (C-term) Blocking peptide; Ras-related protein Rab-11B; GTP-binding protein YPT3; YPT3; RAB11B blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 218

• Cellular Location: Recycling endosome membrane; Lipid-anchor; Cytoplasmic side Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note: Recruited to phagosomes containing S.aureus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RAB11B blocking peptide

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage- gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.

NCBI and Uniprot Product Information

• NCBI GI #: 38258938
• NCBI GeneID: 9230
• UniProt Accession #: Q15907; Q2YDT2; Q5U0I1; Q6FHR0; Q6FI42; Q8NI07; A5YM50; B2R7I4; B4DMK0; D6W671
• Molecular Weight: 19,971 Da
• NCBI Official Full Name: Ras-related protein Rab-11B
• NCBI Official Synonym Full Names: RAB11B, member RAS oncogene family
• NCBI Official Symbol: RAB11B
• NCBI Official Synonym Symbols: H-YPT3
• NCBI Protein Information: ras-related protein Rab-11B
• UniProt Protein Name: Ras-related protein Rab-11B
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB11B
• UniProt Synonym Gene Names: YPT3
• UniProt Entry Name: RB11B_HUMAN

NCBI Description

The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

Uniprot Description

RAB11B: GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cell junction; microtubule organizing center; phagocytic vesicle; plasma membrane; recycling endosome; synaptic vesicle

Molecular Function: GDP binding; GTP binding; GTPase activity; myosin V binding; protein binding

Biological Process: constitutive secretory pathway; melanosome transport; receptor recycling; regulated secretory pathway; transferrin transport