PTPRZ1 blocking peptide

PTPRZ1 Blocking Peptide (N-term)

• Gene Names: PTPRZ1; PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2
• Synonyms: PTPRZ1; PTPRZ1 Blocking Peptide (N-term); Receptor-type tyrosine-protein phosphatase zeta; R-PTP-zeta; Protein-tyrosine phosphatase receptor type Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 2; R-PTP-zeta-2; HTPZP2; PTPRZ; PTPRZ2; PTPZ; PTPRZ1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 446-460 of HUMAN PTPRZ1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 2315

• Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Secreted. Note: A secreted form is apparently generated by shedding of the extracellular domain
• Tissue Location: Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PTPRZ1 blocking peptide

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 229485537
• NCBI GeneID: 5803
• UniProt Accession #: P23471; O76043; Q9UDR6; A4D0W5; C9JFM0
• Molecular Weight: 162,663 Da
• NCBI Official Full Name: Receptor-type tyrosine-protein phosphatase zeta
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type Z1
• NCBI Official Symbol: PTPRZ1
• NCBI Official Synonym Symbols: PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase zeta
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase zeta
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRZ1
• UniProt Synonym Gene Names: HTPZP2; PTPRZ; PTPRZ2; PTPZ; R-PTP-zeta
• UniProt Entry Name: PTPRZ_HUMAN

NCBI Description

This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Uniprot Description

PTPRZ1: May be involved in the regulation of specific developmental processes in the CNS. Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor protein phosphatase, tyrosine; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 7q31.3

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity

Biological Process: central nervous system development; learning and/or memory; oligodendrocyte differentiation; protein amino acid dephosphorylation

Disease: Helicobacter Pylori Infection, Susceptibility To