PRMT3 blocking peptide

PRMT3 Antibody (C-term) Blocking Peptide

• Gene Names: PRMT3; HRMT1L3
• Synonyms: PRMT3; PRMT3 Antibody (C-term) Blocking Peptide; Protein arginine N-methyltransferase 3; 211-; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3; HRMT1L3; PRMT3 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 456~472 of human PRMT3.
• Form/Format: Lyophilized with 100% acetonitrile and is supplied as a powder.
• Sequence Length: 531

• Reconstitution: Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PRMT3 blocking peptide

Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all 7 PRMT members have been developed.

NCBI and Uniprot Product Information

• NCBI GI #: 44771198
• NCBI GeneID: 10196
• NCBI Accession #: NP_005779.1
• NCBI GenBank Nucleotide #: NM_005788.4
• UniProt Accession #: O60678; Q922H1
• NCBI Official Full Name: protein arginine N-methyltransferase 3 isoform 1
• NCBI Official Synonym Full Names: protein arginine methyltransferase 3
• NCBI Official Symbol: PRMT3
• NCBI Official Synonym Symbols: HRMT1L3
• NCBI Protein Information: protein arginine N-methyltransferase 3
• UniProt Protein Name: Protein arginine N-methyltransferase 3
• Protein Family: Protein arginine N-methyltransferase
• UniProt Gene Name: PRMT3
• UniProt Synonym Gene Names: HRMT1L3
• UniProt Entry Name: ANM3_HUMAN

NCBI Description

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Description

PRMT3: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. Belongs to the protein arginine N-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; EC 2.1.1.-; Methyltransferase; Methyltransferase, protein arginine

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: cytosol

Molecular Function: histone-arginine N-methyltransferase activity; methyltransferase activity; protein binding; protein-arginine omega-N asymmetric methyltransferase activity

Biological Process: negative regulation of protein ubiquitination; regulation of transcription, DNA-dependent