PPARD blocking peptide

PPARD Peptide - N-terminal region

Cat. Num. AAA3229229

• Gene Names: PPARD; FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB
• Applications: Immunohistochemistry, Western Blot
• Synonyms: PPARD; PPARD Peptide - N-terminal region; PPARD blocking peptide

• Form/Format: Lyophilized powder
• Sequence Length: 441

• Applicable Applications for PPARD blocking peptide: Immunohistochemistry (IHC), Western Blot (WB)
• Preparation and Storage: Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Related Product Information for PPARD blocking peptide

This is a synthetic peptide designed for use in combination with anti-PPARD antibody made

Target Description: PPARD is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR delta and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

Product Categories/Family for PPARD blocking peptide

Peptide

NCBI and Uniprot Product Information

• NCBI GI #: 89276760
• NCBI GeneID: 5467
• NCBI Accession #: NP_001034783
• NCBI GenBank Nucleotide #: NM_001039694
• Molecular Weight: 49kDa
• NCBI Official Synonym Full Names: peroxisome proliferator activated receptor delta
• NCBI Official Symbol: PPARD
• NCBI Official Synonym Symbols: FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB
• NCBI Protein Information: peroxisome proliferator-activated receptor delta
• Protein Family: Peroxisome proliferator-activated receptor

NCBI Description

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]