PODXL2 blocking peptide

PODXL2 Antibody (C-term) Blocking peptide

• Gene Names: PODXL2; EG; PODLX2
• Synonyms: PODXL2; PODXL2 Antibody (C-term) Blocking peptide; Podocalyxin-like protein 2; Endoglycan; PODXL2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of PODXL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 605

• Cellular Location: Membrane; Single-pass type I membrane protein
• Tissue Location: Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PODXL2 blocking peptide

Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins.

NCBI and Uniprot Product Information

• NCBI GI #: 74734719
• NCBI GeneID: 50512
• UniProt Accession #: Q9NZ53; Q6UVY4; Q8WUV6
• Molecular Weight: 56,635 Da
• NCBI Official Full Name: Podocalyxin-like protein 2
• NCBI Official Synonym Full Names: podocalyxin like 2
• NCBI Official Symbol: PODXL2
• NCBI Official Synonym Symbols: EG; PODLX2
• NCBI Protein Information: podocalyxin-like protein 2
• UniProt Protein Name: Podocalyxin-like protein 2
• Protein Family: Podocalyxin-like protein
• UniProt Gene Name: PODXL2
• UniProt Entry Name: PDXL2_HUMAN

NCBI Description

This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]

Uniprot Description

PODXL2: Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins. Belongs to the podocalyxin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: integral to plasma membrane

Molecular Function: glycosaminoglycan binding; protein binding

Biological Process: leukocyte tethering or rolling