PLEKHA8 blocking peptide

PLEKHA8 Antibody (C-term) Blocking Peptide

• Gene Names: PLEKHA8; FAPP2
• Synonyms: PLEKHA8; PLEKHA8 Antibody (C-term) Blocking Peptide; Pleckstrin homology domain-containing family A member 8; PH domain-containing family A member 8; Phosphatidylinositol-four-phosphate adapter protein 2; FAPP-2; Phosphoinositol 4-phosphate adapter protein 2; hFAPP2; Serologically defined breast cancer antigen NY-BR-86; FAPP2; PLEKHA8 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 519

• Cellular Location: Cytoplasm. Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein Note: Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes
• Tissue Location: Expressed in kidney cell lines.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PLEKHA8 blocking peptide

Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.

NCBI and Uniprot Product Information

• NCBI GI #: 387912902
• NCBI GeneID: 84725
• UniProt Accession #: Q96JA3; Q7Z5V8; Q9BU78; Q9H274; Q9H8Z7; B4DH00
• Molecular Weight: 49,462 Da
• NCBI Official Full Name: Pleckstrin homology domain-containing family A member 8
• NCBI Official Synonym Full Names: pleckstrin homology domain containing A8
• NCBI Official Symbol: PLEKHA8
• NCBI Official Synonym Symbols: FAPP2
• NCBI Protein Information: pleckstrin homology domain-containing family A member 8
• UniProt Protein Name: Pleckstrin homology domain-containing family A member 8
• Protein Family: Pleckstrin homology domain-containing family
• UniProt Gene Name: PLEKHA8
• UniProt Synonym Gene Names: FAPP2; PH domain-containing family A member 8; FAPP-2; Phosphoinositol 4-phosphate adapter protein 2; hFAPP2
• UniProt Entry Name: PKHA8_HUMAN

Uniprot Description

PLEKHA8: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: trans-Golgi network

Molecular Function: glycolipid binding; glycolipid transporter activity

Biological Process: lipid transport