Plau blocking peptide

Mouse Plau Blocking Peptide (C-term)

• Gene Names: Plau; uPA; u-PA
• Synonyms: Plau; Mouse Plau Blocking Peptide (C-term); Urokinase-type plasminogen activator; U-plasminogen activator; uPA; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B; Plau blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 433

• Cellular Location: Secreted.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Plau blocking peptide

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

NCBI and Uniprot Product Information

• NCBI GI #: 137113
• NCBI GeneID: 18792
• UniProt Accession #: P06869
• Molecular Weight: 48,268 Da
• NCBI Official Full Name: Urokinase-type plasminogen activator
• NCBI Official Synonym Full Names: plasminogen activator, urokinase
• NCBI Official Symbol: Plau
• NCBI Official Synonym Symbols: uPA; u-PA
• NCBI Protein Information: urokinase-type plasminogen activator
• UniProt Protein Name: Urokinase-type plasminogen activator
• Protein Family: Urokinase-type plasminogen activator
• UniProt Gene Name: Plau
• UniProt Synonym Gene Names: U-plasminogen activator; uPA
• UniProt Entry Name: UROK_MOUSE

Uniprot Description

uPA: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. Defects in PLAU are the cause of Quebec platelet disorder (QPD). QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 3.4.21.73; Protease; Secreted; Secreted, signal peptide

Cellular Component: cell surface; extracellular space; focal adhesion; membrane

Molecular Function: peptidase activity; protein binding; serine-type endopeptidase activity

Biological Process: angiogenesis; fibrinolysis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of smooth muscle cell migration; proteolysis; regulation of cell adhesion mediated by integrin; regulation of cell proliferation; regulation of receptor activity; regulation of smooth muscle cell migration; response to hypoxia; skeletal muscle regeneration; smooth muscle cell migration; wound healing