Piezo1 blocking peptide

Piezo1 Blocking Peptide

Gene Names

PIEZO1; DHS; Mib; FAM38A

Applications

Blocking/Control

Purity

The purity is >90%,tested by HPLC and MS.

Synonyms

Piezo1; Piezo1 Blocking Peptide; DHS; Fam38a; Family with sequence similarity 38 member A; KIAA0233; Membrane protein induced by beta-amyloid treatment; Mib; PIEZ1_HUMAN; Piezo-type mechanosensitive ion channel component 1; PIEZO1; Protein FAM38A; Protein FAM38B; Protein PIEZO1; Piezo1 blocking peptide

Ordering
Cat. Num. AAA9620788 For Research Use Only!

Purity/Purification

The purity is >90%,tested by HPLC and MS.

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

Applicable Applications for Piezo1 blocking peptide

Blocking/Control

Notes

For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Piezo1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

NCBI GI #

257196142

NCBI GeneID

9780

NCBI Accession #

NP_001136336.2

NCBI GenBank Nucleotide #

NM_001142864.4

UniProt Accession #

Q92508; Q0KKZ9; A6NHT9; A7E2B7

Molecular Weight

286,790 Da

NCBI Official Full Name

piezo-type mechanosensitive ion channel component 1

NCBI Official Synonym Full Names

piezo type mechanosensitive ion channel component 1

NCBI Official Symbol

PIEZO1

NCBI Official Synonym Symbols

DHS; Mib; FAM38A

NCBI Protein Information

piezo-type mechanosensitive ion channel component 1

UniProt Protein Name

Piezo-type mechanosensitive ion channel component 2

Protein Family

Piezo-type mechanosensitive ion channel component

UniProt Gene Name

PIEZO2

UniProt Synonym Gene Names

C18orf30; C18orf58; FAM38B

NCBI Description

The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015]

Uniprot Description

FAM38B: Component of mechanosensitive channel required for rapidly adaptating mechanically activated (MA) currents in DRG neurons. Belongs to the PIEZO family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 18p11.22-p11.21

Cellular Component: plasma membrane

Molecular Function: cation channel activity; mechanically-gated ion channel activity

Biological Process: cation transport; detection of mechanical stimulus; detection of mechanical stimulus involved in sensory perception; regulation of membrane potential; response to mechanical stimulus

Research Articles on Piezo1

1. PIEZO1 is permeable to monovalent ions (K+, Na+, Cs+, Li+) and most divalent ions (Ba2+, Ca2+ and Mg2+), but not to Mn2+.

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Product Notes

The Piezo1 piezo2 (Catalog #AAA9620788) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Piezo1 can be used in a range of immunoassay formats including, but not limited to, Blocking/Control. Researchers should empirically determine the suitability of the Piezo1 piezo2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Piezo1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Piezo1 blocking peptide