Phospho-Annexin A2 Blocking Peptide | ANXA2 blocking peptide

Phospho-Annexin A2 Peptide

Cat. Num. AAA544115

• Gene Names: ANXA2; P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270
• Applications: Immunodepletion, Immunocompetition
• Synonyms: Phospho-Annexin A2; Phospho-Annexin A2 Peptide; Annexin A2; Annexin II; heavy chain; ANX2; ANX2L4; arylsulfatase B; CAL1H; Calpactin I heavy chain; chromobindin 8; Epididymis secretory protein Li 270; HEL S 270; LIP2; Lipocortin II; LPC2; LPC2D; P36; PAP-IV; placental anticoagulant protein IV; Protein I antibody; ANXA2 blocking peptide

• Form/Format: Antigenic Blocking Peptide
• Concentration: Quantity: 250 ug; Volume: 100 ul (varies by lot)
• Sequence Length: 339

• Applicable Applications for ANXA2 blocking peptide: Immunodepletion, Immunocompetition
• Application Notes: Western Blot: 1:500
• Immunogen: Synthetic peptide corresponding to Human Annexin A2 protein with phosphorylated serine 12 and threonine 18 residues. Synthetic peptide was taken within amino acid region 1-50.
• Modification: Phosphorylated
• Molecular Function: calcium-dependent phospholipid binding, calcium ion binding, calcium-dependent protein binding
• Structure: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF. Interacts with human cytomegalovirus (HCMV). Interacts with COCH.
• Subcellular Location: Secreted degree Extracellular space degree extracellular matrix degree basement membrane
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for ANXA2 blocking peptide

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

NCBI and Uniprot Product Information

• NCBI GI #: 30962862
• NCBI GeneID: 302
• UniProt Accession #: P07355; Q567R4; Q6N0B3; Q8TBV2; Q96DD5; Q9UDH8
• Molecular Weight: 40,411 Da
• NCBI Official Full Name: Annexin A2
• NCBI Official Synonym Full Names: annexin A2
• NCBI Official Symbol: ANXA2
• NCBI Official Synonym Symbols: P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270
• NCBI Protein Information: annexin A2
• UniProt Protein Name: Annexin A2
• Protein Family: Annexin
• UniProt Gene Name: ANXA2
• UniProt Synonym Gene Names: ANX2; ANX2L4; CAL1H; LPC2D; PAP-IV
• UniProt Entry Name: ANXA2_HUMAN

NCBI Description

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ANXA2: a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Heterotetramer containing 2 light chains of S100A10 2 heavy chains of ANXA2. May cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Motility/polarity/chemotaxis; Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 15q22.2

Cellular Component: basement membrane; basolateral plasma membrane; cell cortex; cell surface; cytosol; early endosome; endosome; extracellular matrix; extracellular space; extrinsic to plasma membrane; late endosome membrane; lipid particle; lipid raft; lysosomal membrane; melanosome; membrane; midbody; nucleus; perinuclear region of cytoplasm; plasma membrane; ruffle; sarcolemma; vesicle

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; cytoskeletal protein binding; phosphatidylinositol-4,5-bisphosphate binding; phospholipase A2 inhibitor activity; protease binding; protein binding; Rab GTPase binding; receptor activator activity

Biological Process: angiogenesis; body fluid secretion; collagen fibril organization; fibrinolysis; lipid raft formation; membrane budding; negative regulation of catalytic activity; negative regulation of low-density lipoprotein receptor catabolic process; negative regulation of receptor internalization; positive regulation of binding; positive regulation of fibroblast proliferation; positive regulation of protein amino acid phosphorylation; positive regulation of vesicle fusion; protein heterotetramerization