PHLDA1 blocking peptide

PHLDA1 Antibody (N-term) Blocking Peptide

• Gene Names: PHLDA1; PHRIP; TDAG51; DT1P1B11
• Synonyms: PHLDA1; PHLDA1 Antibody (N-term) Blocking Peptide; Pleckstrin homology-like domain family A member 1; Apoptosis-associated nuclear protein; Proline- and glutamine-rich protein; PQ-rich protein; PQR protein; Proline- and histidine-rich protein; T-cell death-associated gene 51 protein; PHRIP; TDAG51; PHLDA1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 401

• Cellular Location: Cytoplasm. Cytoplasmic vesicle membrane. Nucleus, nucleolus. Note: Colocalizes with intracellular vesicles
• Tissue Location: Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PHLDA1 blocking peptide

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.

NCBI and Uniprot Product Information

• NCBI GI #: 229463035
• NCBI GeneID: 22822
• UniProt Accession #: Q8WV24; Q15184; Q2TAN2; Q9NZ17; A1A4G9
• Molecular Weight: 45,016 Da
• NCBI Official Full Name: Pleckstrin homology-like domain family A member 1
• NCBI Official Synonym Full Names: pleckstrin homology like domain family A member 1
• NCBI Official Symbol: PHLDA1
• NCBI Official Synonym Symbols: PHRIP; TDAG51; DT1P1B11
• NCBI Protein Information: pleckstrin homology-like domain family A member 1
• UniProt Protein Name: Pleckstrin homology-like domain family A member 1
• Protein Family: Pleckstrin homology-like domain family
• UniProt Gene Name: PHLDA1
• UniProt Synonym Gene Names: PHRIP; TDAG51; PQ-rich protein; PQR protein
• UniProt Entry Name: PHLA1_HUMAN

NCBI Description

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]

Uniprot Description

PHLDA1: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.

Protein type: Nucleolus; Apoptosis

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: cytosol

Molecular Function: protein binding

Biological Process: G2/M transition of mitotic cell cycle