PDI blocking peptide

PDI Blocking Peptide

Cat. Num. AAA9626907

• Gene Names: PDIA2; PDI; PDA2; PDIP; PDIR
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: PDI; PDI Blocking Peptide; Pancreas-specific protein disulfide isomerase; pancreatic protein disulfide isomerase; PDIA2; PDIA2_HUMAN; PDIp; PDIR; protein disulfide isomerase family A member 2; protein disulfide isomerase; pancreatic; protein disulfide isomerase-associated 2; Protein disulfide-isomerase A2; Rho GDP dissociation inhibitor gamma; PDI blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for PDI blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PDI blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 94966757
• NCBI GeneID: 64714
• NCBI Accession #: NP_006840.2
• NCBI GenBank Nucleotide #: NM_006849.3
• UniProt Accession #: Q13087; Q2WGM4; Q4TT67; Q6B010; Q96KJ6; Q9BW95; A6ZJ64; B4DI27
• Molecular Weight: 58206 MW
• NCBI Official Full Name: protein disulfide-isomerase A2
• NCBI Official Synonym Full Names: protein disulfide isomerase family A member 2
• NCBI Official Symbol: PDIA2
• NCBI Official Synonym Symbols: PDI; PDA2; PDIP; PDIR
• NCBI Protein Information: protein disulfide-isomerase A2
• UniProt Protein Name: Protein disulfide-isomerase A2
• UniProt Gene Name: PDIA2
• UniProt Synonym Gene Names: PDIP; PDIp

NCBI Description

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]

Uniprot Description

Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.