PDE6A blocking peptide

PDE6A Antibody (Center) Blocking Peptide

• Gene Names: PDE6A; PDEA; RP43; CGPR-A
• Synonyms: PDE6A; PDE6A Antibody (Center) Blocking Peptide; Rod cGMP-specific 3';5'-cyclic phosphodiesterase subunit alpha; GMP-PDE alpha; PDE V-B1; PDEA; PDE6A blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of PDE6A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 860

• Cellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PDE6A blocking peptide

This protein participates in processes of transmission and amplification of the visual signal.

NCBI and Uniprot Product Information

• NCBI GI #: 215274230
• NCBI GeneID: 5145
• UniProt Accession #: P16499; Q0P638
• Molecular Weight: 99,547 Da
• NCBI Official Full Name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
• NCBI Official Synonym Full Names: phosphodiesterase 6A
• NCBI Official Symbol: PDE6A
• NCBI Official Synonym Symbols: PDEA; RP43; CGPR-A
• NCBI Protein Information: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
• UniProt Protein Name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
• Protein Family: Rod cGMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE6A
• UniProt Synonym Gene Names: PDEA; GMP-PDE alpha
• UniProt Entry Name: PDE6A_HUMAN

NCBI Description

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]

Uniprot Description

PDE6A: This protein participates in processes of transmission and amplification of the visual signal. Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43). RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the cyclic nucleotide phosphodiesterase family.

Protein type: EC 3.1.4.35; Phosphodiesterase

Chromosomal Location of Human Ortholog: 5q31.2-q34

Cellular Component: plasma membrane

Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity

Biological Process: cytosolic calcium ion homeostasis; GMP metabolic process; regulation of rhodopsin mediated signaling; rhodopsin mediated signaling; Wnt receptor signaling pathway, calcium modulating pathway

Disease: Retinitis Pigmentosa 43