OGDH blocking peptide

OGDH Antibody (C-term) Blocking peptide

• Gene Names: OGDH; E1k; OGDC; AKGDH
• Synonyms: OGDH; OGDH Antibody (C-term) Blocking peptide; 2-oxoglutarate dehydrogenase; mitochondrial; 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase; OGDH blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of OGDH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1023

• Cellular Location: Mitochondrion matrix.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for OGDH blocking peptide

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

NCBI and Uniprot Product Information

• NCBI GI #: 160332299
• NCBI GeneID: 4967
• UniProt Accession #: Q02218; Q96DD3; Q9UDX0; B4E2U9; D3DVL0; E9PBM1
• Molecular Weight: 48,180 Da
• NCBI Official Full Name: 2-oxoglutarate dehydrogenase, mitochondrial
• NCBI Official Synonym Full Names: oxoglutarate dehydrogenase
• NCBI Official Symbol: OGDH
• NCBI Official Synonym Symbols: E1k; OGDC; AKGDH
• NCBI Protein Information: 2-oxoglutarate dehydrogenase, mitochondrial
• UniProt Protein Name: 2-oxoglutarate dehydrogenase, mitochondrial
• UniProt Gene Name: OGDH
• UniProt Synonym Gene Names: OGDC-E1
• UniProt Entry Name: ODO1_HUMAN

NCBI Description

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

Uniprot Description

OGDH: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the alpha-ketoglutarate dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.2.4.2; Mitochondrial; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - citrate (TCA) cycle; Oxidoreductase

Chromosomal Location of Human Ortholog: 7p14-p13

Cellular Component: cytosol; mitochondrial matrix; mitochondrial membrane; mitochondrion; oxoglutarate dehydrogenase complex

Molecular Function: oxoglutarate dehydrogenase (succinyl-transferring) activity

Biological Process: generation of precursor metabolites and energy; glyoxylate metabolic process; lysine catabolic process; tricarboxylic acid cycle

Disease: Alpha-ketoglutarate Dehydrogenase Deficiency