Rabbit anti-Human PTPRN2 Polyclonal Antibody | anti-PTPRN2 antibody

PTPRN2 (Protein Tyrosine Phosphatase IA-2 Beta, Receptor-type Tyrosine-protein Phosphatase N2, R-PTP-N2, Islet Cell Autoantigen-related Protein, IAR, ICAAR, Phogrin, KIAA0387)

Cat. Num. AAA6007124

• Gene Names: PTPRN2; IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PTPRN2; Polyclonal Antibody; PTPRN2 (Protein Tyrosine Phosphatase IA-2 Beta; Receptor-type Tyrosine-protein Phosphatase N2; R-PTP-N2; Islet Cell Autoantigen-related Protein; IAR; ICAAR; Phogrin; KIAA0387); Anti -PTPRN2 (Protein Tyrosine Phosphatase IA-2 Beta; anti-PTPRN2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PTPRN2.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLGCLLEEGLCGASEACVNDGVFGRCQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVAHTSALTYPPGPRTQLREDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSSTGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGESGEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDREVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGADATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ

• Applicable Applications for anti-PTPRN2 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human PTPRN2, aa1-986 (NP_570858.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of PTPRN2 expression in transfected 293T cell line by PTPRN2 polyclonal antibody. Lane 1: PTPRN2 transfected lysate (108.1kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-PTPRN2 antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Product Categories/Family for anti-PTPRN2 antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 47939489
• NCBI GeneID: 5799
• UniProt Accession #: Q92932; Q8N4I5; Q92662; Q9Y4F8; Q9Y4I6; E9PC57
• Molecular Weight: 111,271 Da
• NCBI Official Full Name: PTPRN2 protein
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, N polypeptide 2
• NCBI Official Symbol: PTPRN2
• NCBI Official Synonym Symbols: IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase N2; phogrin; tyrosine phosphatase IA-2 beta; islet cell autoantigen-related protein; protein tyrosine phosphatase receptor pi; IAR/receptor-like protein-tyrosine phosphatase
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase N2
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRN2
• UniProt Synonym Gene Names: KIAA0387; R-PTP-N2; IAR; ICAAR
• UniProt Entry Name: PTPR2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

PTPRN2: Implicated in development of nervous system and pancreatic endocrine cells. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: integral to plasma membrane; endoplasmic reticulum lumen; terminal button; receptor complex; secretory granule

Molecular Function: transmembrane receptor protein tyrosine phosphatase activity

Biological Process: protein amino acid dephosphorylation