NUP88 blocking peptide

NUP88 Peptide

Cat. Num. AAA3006048

• Gene Names: NUP88; FADS4
• Applications: Blocking
• Purity: Synthetic peptide NUP88. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: NUP88; NUP88 Peptide; Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup88; NUP88 blocking peptide

• Specificity: This peptide can be used with studies using MBS3006047 NUP88 pAb.
• Purity/Purification: Synthetic peptide NUP88. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 741

• Applicable Applications for NUP88 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for NUP88 blocking peptide

The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup88 (nucleoporin 88kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex. Expressed ubiquitously, Nup88 is subject to phosphorylation by ATM or ATR and is upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis. The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1, 200 genes.

NCBI and Uniprot Product Information

• NCBI GI #: 24497453
• NCBI GeneID: 4927
• NCBI Accession #: NP_002523.2
• NCBI GenBank Nucleotide #: NP_002523.2
• UniProt Accession #: Q99567
• NCBI Official Full Name: nuclear pore complex protein Nup88 isoform 2
• NCBI Official Synonym Full Names: nucleoporin 88
• NCBI Official Symbol: NUP88
• NCBI Official Synonym Symbols: FADS4
• NCBI Protein Information: nuclear pore complex protein Nup88
• UniProt Protein Name: Nuclear pore complex protein Nup88
• UniProt Gene Name: NUP88
• UniProt Entry Name: NUP88_HUMAN

NCBI Description

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Uniprot Description

Function: Essential component of nuclear pore complex.

Subunit structure: Interacts with NUP214/CAN. Ref.1

Subcellular location: Nucleus › nuclear pore complex.

Tissue specificity: Ubiquitous.