Rabbit NUP88 Polyclonal Antibody | anti-NUP88 antibody

NUP88 Polyclonal Antibody

Cat. Num. AAA3006047

• Gene Names: NUP88; FADS4
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: NUP88; Polyclonal Antibody; NUP88 Polyclonal Antibody; Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup88; anti-NUP88 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: NUP88 polyclonal antibody detects endogenous levels of NUP88 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 741

• Applicable Applications for anti-NUP88 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 399-444 of Human NUP88.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of NUP88 polyclonal antibody at 1:500 dilutionLane1:Hela cell lysateLane2:NIH-3T3 cell lysateLane3:H9C2 cell lysate)

Related Product Information for anti-NUP88 antibody

The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup88 (nucleoporin 88kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex. Expressed ubiquitously, Nup88 is subject to phosphorylation by ATM or ATR and is upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis. The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1, 200 genes.

NCBI and Uniprot Product Information

• NCBI GI #: 24497453
• NCBI GeneID: 4927
• NCBI Accession #: NP_002523.2
• NCBI GenBank Nucleotide #: NP_002523.2
• UniProt Accession #: Q99567
• Molecular Weight: ~ 88kDa
• NCBI Official Full Name: nuclear pore complex protein Nup88 isoform 2
• NCBI Official Synonym Full Names: nucleoporin 88
• NCBI Official Symbol: NUP88
• NCBI Official Synonym Symbols: FADS4
• NCBI Protein Information: nuclear pore complex protein Nup88
• UniProt Protein Name: Nuclear pore complex protein Nup88
• UniProt Gene Name: NUP88
• UniProt Entry Name: NUP88_HUMAN

NCBI Description

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Uniprot Description

Function: Essential component of nuclear pore complex.

Subunit structure: Interacts with NUP214/CAN. Ref.1

Subcellular location: Nucleus › nuclear pore complex.

Tissue specificity: Ubiquitous.