Nkx3-1 blocking peptide

Mouse Nkx3-1 Antibody (Center) Blocking Peptide

• Gene Names: Nkx3-1; Bax; NKX3A; NKX3.1; Nkx-3.1; bagpipe
• Synonyms: Nkx3-1; Mouse Nkx3-1 Antibody (Center) Blocking Peptide; Homeobox protein Nkx-31; Homeobox protein NK-3 homolog A; Nkx-31; Nkx3a; Nkx3-1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 237

• Cellular Location: Nucleus
• Tissue Location: Expressed mostly in the male urogenital tract, with highest expression in the epithelial cells lining the ducts of anterior, dorsolateral and ventral prostate and in the bulbourethral gland, and much lower in the seminal vesicle and the testis. Expression in the prostate increases during sexual maturation and is drastically reduced following castration Expressed also in brain (hippocampus and external granular layer of the cerebral cortex), kidney (intralobular arteries), thymus and adrenal and salivary glands
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Nkx3-1 blocking peptide

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for appropriate differentiation and secretory function of the bulbourethral gland.

NCBI and Uniprot Product Information

• NCBI GI #: 3023954
• NCBI GeneID: 18095
• UniProt Accession #: P97436; O09087
• Molecular Weight: 26,824 Da
• NCBI Official Full Name: Homeobox protein Nkx-3.1
• NCBI Official Synonym Full Names: NK-3 transcription factor, locus 1 (Drosophila)
• NCBI Official Symbol: Nkx3-1
• NCBI Official Synonym Symbols: Bax; NKX3A; NKX3.1; Nkx-3.1; bagpipe
• NCBI Protein Information: homeobox protein Nkx-3.1
• UniProt Protein Name: Homeobox protein Nkx-3.1
• Protein Family: Homeobox protein
• UniProt Gene Name: Nkx3-1
• UniProt Synonym Gene Names: Nkx-3.1; Nkx3a
• UniProt Entry Name: NKX31_MOUSE

Uniprot Description

NKX3-1: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Interacts with serum response factor (SRF). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation. By androgens and, in the LNCAP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen- independent phase. Highly expressed in the prostate and, at a lower level, in the testis. Belongs to the NK-3 homeobox family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Transcription factor; DNA-binding

Cellular Component: intracellular; nucleus

Molecular Function: androgen receptor activity; caspase activator activity; DNA binding; estrogen receptor activity; estrogen receptor binding; histone deacetylase binding; protein binding; protein kinase activator activity; protein self-association; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: androgen receptor signaling pathway; branching morphogenesis of a tube; caspase activation; internal genitalia morphogenesis; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of mitotic cell cycle; negative regulation of transcription, DNA-dependent; positive regulation of caspase activity; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of mitotic cell cycle; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; prostate gland development; protein kinase B signaling cascade; response to testosterone stimulus; salivary gland development; urogenital system development