NDUFA13 blocking peptide

NDUFA13 Antibody (N-term) Blocking Peptide

• Gene Names: NDUFA13; B16.6; CDA016; CGI-39; GRIM19; GRIM-19
• Synonyms: NDUFA13; NDUFA13 Antibody (N-term) Blocking Peptide; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Cell death regulatory protein GRIM-19; Complex I-B166; CI-B166; Gene associated with retinoic and interferon-induced mortality 19 protein; GRIM-19; Gene associated with retinoic and IFN-induced mortality 19 protein; NADH-ubiquinone oxidoreductase B166 subunit; GRIM19; NDUFA13 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 144

• Cellular Location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus. Note: May be translocated into the nucleus upon IFN/RA treatment
• Tissue Location: Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NDUFA13 blocking peptide

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.

NCBI and Uniprot Product Information

• NCBI GI #: 20139242
• NCBI GeneID: 51079
• UniProt Accession #: Q9P0J0; Q6PKI0; Q9H2L3; Q9Y327; B4DF76; K7EK58
• Molecular Weight: 24,882 Da
• NCBI Official Full Name: NADH dehydrogenase
• NCBI Official Synonym Full Names: NADH:ubiquinone oxidoreductase subunit A13
• NCBI Official Symbol: NDUFA13
• NCBI Official Synonym Symbols: B16.6; CDA016; CGI-39; GRIM19; GRIM-19
• NCBI Protein Information: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
• UniProt Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
• Protein Family: NADH dehydrogenase
• UniProt Gene Name: NDUFA13
• UniProt Synonym Gene Names: GRIM19; CI-B16.6; GRIM-19; Gene associated with retinoic and IFN-induced mortality 19 protein
• UniProt Entry Name: NDUAD_HUMAN

NCBI Description

This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]

Uniprot Description

GRIM-19: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. Defects in NDUFA13 may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC). Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms. Belongs to the complex I NDUFA13 subunit family.

Protein type: Oxidoreductase; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrial membrane; mitochondrial respiratory chain; mitochondrial respiratory chain complex I; mitochondrion; nucleoplasm

Molecular Function: NADH dehydrogenase (ubiquinone) activity; NADH dehydrogenase activity; protein binding

Biological Process: mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; positive regulation of caspase activity; positive regulation of protein catabolic process; protein import into mitochondrial inner membrane

Disease: Thyroid Carcinoma, Hurthle Cell